Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown.
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown.
In addition cigarette smoke exposure can make some strains of Staphylococcus aureus -- a microbe present in 30 percent to 60 percent of the global population and responsible for many diseases, some fatal -- more invasive and persistent, although the effect is not universal across all strains tested.
The researchers believe the stress cigarette smoke causes to S. aureus sparks an emergency 'SOS' response, which increases the rate of mutation in microbial DNA, resulting in hardy and persistent variants better able to resist antibiotics.
Previous studies had attributed smokers' increased susceptibility to infection to the damaging effects of smoke on our immune system, but this study shows that it may also be changing the DNA and characteristics of pathogenic microbes as well.
In a series of lab-based experiments the researchers from Bath, working with colleagues from Imperial College London, University of Oxford and Institut d'Investigació Germans Trias i Pujol, Universitat Autònoma de Barcelona and CIBER Enfermedades Respiratorias, Spain, exposed six reference strains of the most important 'superbug' Methicillin- Resistant S. aureus (MRSA) clones to cigarette smoke.
The strains were known to cause conditions ranging from skin infections to pneumonia and endocarditis and were chosen for their clinical relevance and genetic diversity. Although not all responded to cigarette smoke in the same way some, including those known to cause invasive infections, showed increased resistance to the antibiotic rifampicin and increased invasiveness and persistence. Resistance to other antibiotics is also likely to be affected.
The study links these changes to the emergence of Small Colony Variants (SCVs) - hardy sub-populations that are adapted to harsh conditions. SCVs have been linked to chronic infections in smokers in previous research.
The study is published in the journal Scientific Reports.
Lead author Dr. Maisem Laabei, from the University of Bath's Department of Biology & Biochemistry, said, "We expected some effects but we didn't anticipate smoke would affect drug-resistance to this degree. We recognize that exposure in a lab is different to inhaled smoke over a long time, but it seems reasonable to hypothesise, based on our research and others' that stressful conditions imposed by smoking induce responses in microbial cells leading to adaptation to harsh conditions, with the net effect of increasing virulence and/or potential for infection. Smoking is the leading cause of preventable death worldwide, and cigarette smoke has over 4,800 compounds within it. We wanted to study S. aureus because it's so common in humans and it can cause a range of diseases, so we wanted to see what happened when we exposed it to smoke. These Small Colony Variants are highly adhesive, invasive and persistent. They can sit around for a long time, are difficult to kick out, and are linked to chronic infections. We hope that our work provides another reason for people not to smoke and for current smokers to quit."
The scientists are now interested in studying how air pollution, from diesel exhaust fumes and other sources, might affect the microbes in our nasal passages as many of the pollution compounds are the same as in cigarette smoke.
The research was supported by a European Respiratory Society Long-term Fellowship grant.
The paper "Cigarette smoke exposure redirects Staphylococcus aureus to a virulence profile associated with persistent infection" is published in Scientific Reports.
Source: University of Bath
Second Strain of Bird Flu Found in US Dairy Cows: What It Means for Infection Prevention and Control
February 7th 2025A new H5N1 strain was found in Nevada dairy cows, challenging earlier transmission theories. This raises concerns about animal vulnerability, human health risks, and food safety. Experts emphasize the need for improved surveillance, biosecurity, and cross-sector collaboration to contain the virus spread.
Fungal Infections: The Silent Epidemic Threatening Global Health
February 6th 2025Fungal infections are a rising global threat, with antifungal resistance complicating treatment. Neil J. Clancy, MD, emphasizes the urgent need for research, better diagnostics, and stronger infection prevention strategies.
Hiding in Plain Sight: The Most Harmful and Costly Hospital-Acquired Infection
February 5th 2025Nonventilator hospital-acquired pneumonia (NV-HAP) is a deadly, overlooked infection impacting patient outcomes. With new diagnostic tools and prevention strategies, hospitals must prioritize oral hygiene to reduce risk.