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Reminders to take medication, delivered to patients via an electronic pillbox, may be able to improve adherence to tuberculosis (TB) treatment. The findings, reported this week in PLOS Medicine, are the result of a cluster randomized controlled trial by Shiwen Jiang of the Chinese Centers for Disease Control & Prevention, Katherine Fielding, of the London School of Hygiene & Tropical Medicine, and colleagues.
The study randomized 36 districts in the provinces of Heilongjiang, Jiangsu, Hunan, and Chongqing, China to receive one of four approaches to tuberculosis case management: medication reminders via text messages (1,008 patients), a medication monitor box (997 patients), both (1,064 patients), or neither (control, 1,104 patients). Medication adherence for the 4,173 TB patients included in the study was monitored by pill counts and the medication monitor box (supplied to all patients but only providing reminders to the appropriate intervention groups).
While patients in the control arm were non-adherent (percentage of patient-months with more than 20 percent of their doses missed) in 29.9 percent of the months, patients who received reminders from the medication box were non-adherent in 17.0 percent of the months, and in only 13.9 percent of months for patients who received reminders via both the medication box and text message. There was no significant difference from control arm for patients receiving text message reminders only. The researchers noted that there were difficulties with the equipment in all arms, including operator error and equipment malfunctions.
In an accompanying Perspective article, John Metcalfe of the University of California San Francisco and colleagues discuss the importance of adherence to TB medication, difficulties with the traditional method of ensuring adherence through directly observed treatment (DOT), and the importance of developing effective new methods that reduce burden to patients and are easier to implement at a large scales and in remote areas.
Metcalfe and colleagues say: "If replicated, [this study] will have important implications for global TB treatment in moving away from witnessed dosing, which is not universally feasible, towards a more personalized adherence model of patient-provider communication in which intervention is delivered where, when, and in whom it is needed to efficiently prevent adverse treatment outcome."
Fielding and colleagues say: "In a setting such as China where universal use of DOT is not feasible, innovative approaches to enable patients to adhere to TB treatment are needed. Widespread use of medication monitors in national TB control programs can benefit from the development of a low-cost and reliable medication monitor as well as evidence that its use can improve clinical outcomes."
The study was funded by the Bill & Melinda Gates Foundation, grant number 51914. The funders (DPC, SH) contributed to design, running of the trial, and preparation of manuscript.
Reference: Liu X, Lewis JJ, Zhang H, Lu W, Zhang S, Zheng G, et al. (2015) Effectiveness of Electronic Reminders to Improve Medication Adherence in Tuberculosis Patients: A Cluster-Randomised Trial. PLoS Med 12(9): e1001876. doi:10.1371/journal.pmed.1001876