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Gabriele Berg, who heads the Institute of Environmental Biotechnology at Graz University of Technology (TU Graz), has initiated an interdisciplinary cooperation project in her research project, plant-associated microbial communities in indoor environment, which is funded by the Austrian Science Fund (FWF). The research group investigated microbial control -- the degree of cleaning and hygiene measures -- and how it influences the development of resistance. Research was carried out together with national partners of the Medical University of Graz in the framework of the BioTechMed-Graz inter-university cooperation and international partners. The results of the research have just been published in Nature Communications.
The researchers compared the microbiome and the resistome -- all existing microorganisms and antibiotic resistance -- at the intensive care unit of the Department of Internal Medicine at University Hospital Graz, with clean rooms subject to strong microbial control in the aerospace industry and with public and private buildings which have hardly any microbial controls.
"The analyses show that microbial diversity decreases in areas with high levels of hygiene but that the diversity of resistances increases. In environments with strong microbial control in the intensive care unit and industrially used clean rooms, there is increasing antibiotic resistance which shows a high potential for combining with pathogens," explains Dr. Alexander Mahnert, director of studies at the Institute of Environmental Biotechnology of TU Graz, who is currently conducting research at the Medical University of Graz.
The results indicate that a stable microbial diversity in clinical areas counteracts the spread of resistance.
"The microbial control of pathogens is already being successfully used in cultivated plants and also in humans in the framework of stool transplantation. Our study provides an initial foundation to pursue such ideas in indoor areas in the future," says Berg.
The deliberate use of useful microorganisms and the reduction of antibacterial cleaning agents could be the first strategies in maintaining or improving microbial diversity.
In a subsequent step, the research team at Graz University of Technology would like to develop and implement biotechnological solutions for a tailor-made microbial diversity.
Source: Graz University of Technology