• ACVC Callout
News
ICViewExpert PerspectivesMedical World NewsVideosWebinars
Conference
Infection Control TodaySupplements And Featured Publications
CME/CEJob BoardPartnersSponsoredWhitepapers
Print SubscriptioneNewsletter
Educator of the Year Nomination FormEducator of the Year Official RulesEducator of the Year
Advanced Technology
Bug of the Month
COVID-19
Environmental Services
HAIs
Hand Hygiene
Long-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Prevention
Sterile Processing
Surface Disinfection
Vascular Access
Spotlight -
  • Expert Perspectives on Personal Protection Guidelines and Standardization Practices
  • Bug of the Month
Advanced Technology
Bug of the Month
COVID-19
Environmental Services
HAIs
Hand Hygiene
Long-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Prevention
Sterile Processing
Surface Disinfection
Vascular Access
    • News
    • Conference
Advertisement

Kansas State University Researchers Map Links Between Salmonella and Sepsis

Sep 16, 2016
Article

Research by industrial engineering and biology researchers at Kansas State University marks a significant milestone in the battle against sepsis, the second highest cause of death in intensive care units in the U.S.

The study, "An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data," was recently published in the peer-reviewed scientific journal PLOS ONE.

Zhenzhen Shi, a December 2015 industrial engineering doctoral graduate and first author; faculty researchers David Ben-Arieh, professor, and John Wu, associate professor, both of industrial engineering; and Stephen Chapes, professor of biology, studied the biological processes that lead to and result from sepsis, a hepatic - or liver-related - inflammatory response.

The research team developed an integrated mathematical and multi-agent-based model to simulate hepatic inflammatory response caused by salmonella. Rapid response is critical to successful treatment, but because of the unpredictable nature of hepatic inflammatory response, sepsis and septic shock are difficult to identify in individual patients.

"Previous research used a simplified mathematical model to represent the progression of a sepsis episode," Ben-Arieh said. "Such a model was not able to capture the full complexity of this health risk."

The new model allows the researchers to more accurately map interactions among cells, tissues and cytokines, which are small proteins important in cell signaling.

"The strength of the current model is the integration of the complex mathematical and biological description with a simulation engine that can model this phenomenon," Wu said.

By modeling the progression of the sepsis episode, Ben-Arieh and Wu said clinicians can provide the most appropriate and timely care to the patient. Future research in this area will incorporate more biological pathways for increasingly accurate simulations.

"Sepsis deaths are difficult to predict without a highly complex hybrid model," Shi said. "This latest model could be the best tool available for predicting and treating sepsis and preventing fatalities."

Shi said that as more human data on sepsis becomes available, this type of work may be further developed into an easy-to-use visualization tool that can predict sepsis progression, test proposed treatments prior to preclinical experiments and eventually help in clinical decision-making.

Shi is currently a postdoctoral fellow at the Institute of Computational Comparative Medicine at Kansas State University.

The study included support for Shi from the industrial and manufacturing systems engineering department. Ben-Arieh and Wu's contributions were supported by the Health Care Operations Resource Center at Kansas State University; and Chapes' work was supported by grants from the National Institutes of Health and National Aeronautics and Space Administration.

Source: Kansas State University

Related Videos
Medical investigators going over data. (AdobeStock 589197902 by Wasan)
CDC logo is seen on a laptop. (Adobe Stock 428450603 by monticellllo)
Association for the Health Care Environment (Logo used with permission)
COVID-19 germs, fungi, bacteria objects. (Adobe Stock 584704860 by chawalit)
Ambassador Deborah Birx, , speaks with Infection Control Today about masks in schools and the newest variant.
mRNA technology  (Adobe Stock 485886181 by kaptn)
Ambassador Deborah Birx, MD
Woman lying in hospital bed (Adobe Stock, unknown)
Photo of a model operating room. (Photo courtesy of Indigo-Clean and Kenall Manufacturing)
Related Content

Evolving Symptomatology: Respiratory Viruses in the Era of COVID-19 Variants

September 27th 2023

I’m Not Just an Infection Preventionist

September 26th 2023

Poll: What Minimum Educational Requirement Should Infection Preventionists Have?

September 25th 2023

How to Prepare For Possible “Tripledemic” of RSV, Influenza, and SARS-CoV-2

September 25th 2023

Weekly Rounds: Data-Driven Action Against COVID-19, Emerging Pathogens, HIV Vaccine Trials Begin, and More

September 22nd 2023

NIH Announces HIV Vaccine Clinical Trial Begins

September 20th 2023

Evolving Symptomatology: Respiratory Viruses in the Era of COVID-19 Variants

September 27th 2023

I’m Not Just an Infection Preventionist

September 26th 2023

Poll: What Minimum Educational Requirement Should Infection Preventionists Have?

September 25th 2023

How to Prepare For Possible “Tripledemic” of RSV, Influenza, and SARS-CoV-2

September 25th 2023

Weekly Rounds: Data-Driven Action Against COVID-19, Emerging Pathogens, HIV Vaccine Trials Begin, and More

September 22nd 2023

NIH Announces HIV Vaccine Clinical Trial Begins

September 20th 2023

Evolving Symptomatology: Respiratory Viruses in the Era of COVID-19 Variants

September 27th 2023

I’m Not Just an Infection Preventionist

September 26th 2023

Poll: What Minimum Educational Requirement Should Infection Preventionists Have?

September 25th 2023

How to Prepare For Possible “Tripledemic” of RSV, Influenza, and SARS-CoV-2

September 25th 2023

Weekly Rounds: Data-Driven Action Against COVID-19, Emerging Pathogens, HIV Vaccine Trials Begin, and More

September 22nd 2023

NIH Announces HIV Vaccine Clinical Trial Begins

September 20th 2023
Related Content
Advertisement

COVID-19 germs, fungi, bacteria objects.   (Adobe Stock 584704860 by chawalit)

Evolving Symptomatology: Respiratory Viruses in the Era of COVID-19 Variants

September 27th 2023
Article

As COVID-19 restrictions eased up, other respiratory viruses began circulating alongside SARS-CoV-2. It's crucial to identify cases and understand the symptoms of these infections to track the evolution of the virus and what health care workers should look out for.


An infection preventionist taking off her mask. (Adobe Stock, unknown)

I’m Not Just an Infection Preventionist

September 26th 2023
Article

Infection preventionists (IP) can come from many different backgrounds. This is 1 opinion from 1 very successful IP who doesn't have an RN or a BSN and the bullying that sometimes occurs.


(Adobe Stock FILE #:  56169337 by thinglass)

Poll: What Minimum Educational Requirement Should Infection Preventionists Have?

September 25th 2023
Article

Many infection preventionists (IPs) disagree on the minimum requirement to have the IP position. Let Infection Control Today know your opinion. Answer this poll, and send your thoughts to Senior Editor Tori Whitacre Martonicz at tmartonicz@mjhlifesciences.com.


Influenza, RSV, and COVID-19 (AdobeStock_249346161, AdobeStock_538653843,AdobeStock_471755796)

How to Prepare For Possible “Tripledemic” of RSV, Influenza, and SARS-CoV-2

September 25th 2023
Article

The interaction between the respiratory viruses SARS-CoV-2, influenza, and RSV, poses ongoing challenges. Personal protective measures, testing, and vaccination are critical components of our strategy to mitigate the impact of these viruses.


weekly rounds with infection control today

Weekly Rounds: Data-Driven Action Against COVID-19, Emerging Pathogens, HIV Vaccine Trials Begin, and More

September 22nd 2023
Article

Take 5 minutes to catch up on Infection Control Today®’s highlights for the week ending September 24, 2023.


NIH Announces HIV Vaccine Clinical Trial Begins

NIH Announces HIV Vaccine Clinical Trial Begins

September 20th 2023
Article

A new preventative vaccine has been developed incorporating technology funded by the NIH since 2004. The trials will be conducted in the United States and South Africa.

Advertise
About Us
Editorial Board
Contact Us
Job Board
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Clarke Drive
Cranbury, NJ 08512

609-716-7777

© 2023 MJH Life Sciences

All rights reserved.
Home
About Us
News