Mobilizing the Immune System to Fight Viruses


Last week marked the 20th anniversary of professors Doherty and Zinkernagel's Nobel Prize in Medicine for discoveries concerning the immune system. Twenty years on, and Monash University-based researchers are making fundamental advances in how our immune system functions.

The key to all immune responses - whether we are fighting off a cold, or our body is trying to eliminate a cancerous cell - are T cells. The T cell is the part of the immune system that recognizes a foreign invader, such as the influenza virus, and triggers the cascade of events that kills such devastating pathogens. But the mechanism by which these T cells are recruited to fight disease has remained unclear.

Now a team of Monash researchers has provided key insight into how T cells 'see' viruses. In a landmark paper in the journal Immunity, researchers from the Monash Biomedicine Discovery Institute and the ARC Centre of Excellence in Advanced Molecular Imaging, have investigated this recognition in the arsenal of T cells that sit in wait to respond to virus infection.

"It was thought that a common mechanism underpinned how our T cells recognized viruses, like a key in a lock" La Gruta said. "But this is not the case. Our data suggests that T cells can recognize viruses in a completely different way, and still 'unlock' a T cell response. This discovery is critical because the way this initial T cell-virus interaction occurs shapes the entire immune response that follows."

Using the National Synchrotron, Dr. Stephanie Gras was able to gain key molecular insights into how the T cell sees the virus, and in doing so, challenged immunological concepts spanning decades.

"This discovery is a major turn-around in the way we think of how the immune system works," La Gruta said.

"It's fitting that on the 20th anniversary of Australian Peter Doherty being awarded The Nobel Prize in Physiology or Medicine with Rolf M. Zinkernagel for their immune system research, we are still unraveling new ways in which the human body fights off disease."

Committed to making the discoveries that will relieve the future burden of disease, the newly established Monash Biomedicine Discovery Institute at Monash University brings together more than 120 internationally-renowned research teams. Our researchers are supported by world-class technology and infrastructure, and partner with industry, clinicians and researchers internationally to enhance lives through discovery.

The $39 million ARC-funded Imaging CoE develops and uses innovative imaging technologies to visualize the molecular interactions that underpin the immune system. Featuring an internationally renowned team of lead scientists across five major Australian Universities and academic and commercial partners globally, the Centre uses a truly multi scale and programmatic approach to imaging to deliver maximum impact.

The Imaging CoE is headquartered at Monash University with four collaborating organizations - La Trobe University, the University of Melbourne, University of New South Wales and the University of Queensland.

Source: Monash University

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