News
ICViewExpert PerspectivesMedical World NewsPathogen PlaybookVideosWebinars
Conference CoverageConference ListingAPIC Chapters
Infection Control TodaySupplements And Featured Publications
CME/CEEditorial Advisory BoardJob BoardPartnersSponsoredWhitepapers
Subscribe
Educator of the Year Official Rules2024 Educator of the Year Winner2023 Educator of the Year WinnerEducator of the Year
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
Spotlight -
  • IC Trends
  • Bug of the Month
  • Featured Articles
  • Featured Columns
  • Pathogen Playbook
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
    • News
    • Subscribe
Advertisement

Rare Infections After Medically Induced Abortions Likely Not Drug-Related

November 6, 2006
Article

Since 2000, five women in North America who had medically induced abortions (MIAs) died from toxic shock caused by a Clostridium sordellii infection. This has led some people to question the safety of the combination of the drugs mifepristone and misoprostol frequently used in MIA procedures.

A new review of C. sordellii infections and an accompanying editorial, both published in the Dec. 1 issue of Clinical Infectious Diseases and currently available online, place these MIA-C. sordellii deaths in perspective and help to clear up misapprehensions.

According to the review by Michael Aldape, PhD, of the Veteran's AffairsMedicalCenter in Boise, ID, nearly 2 million women in Europe have used mifepristone and no C. sordellii infections or deaths have been reported. Since 2000, more than 600,000 women in the United States have undergone mifepristone-induced abortion, with four reported deaths. Also, prior to the cases in the United States, one woman in Canada who had had a MIA subsequently acquired a fatal C. sordellii infection.

In addition, Aldape reviews 40 other deaths caused by C. sordellii infections. These infections most commonly followed childbirth, injection drug use, trauma, or surgery.

Aldape said, "while there have been a handful of C. sordellii-related deaths stemming from mifepristone/misoprostol usage in the past few years, I believe the problem is more global....There are many examples of non-gynecological infections due to C. sordellii in the literature, of which more than half were fatal."

Beverly Winikoff, MD, MPH, of the Gynuity Health Projects organization and author of an accompanying editorial, argues against theories that there is a connection between C. sordellii infections and the drugs mifepristone and misoprostol.  She said, "The importance of articles like [Aldape's review] is to point out that C. sordellii infections are a broader problemit's a big intellectual and strategic error to focus on medical abortions. This is an infectious diseases issue."

In her editorial, Winikoff points out that most of the explanations that have been put forward to connect C. sordellii with mifepristone do not have sufficient scientific basis. Nevertheless, what she calls "a large natural experiment" is now occurring in this country as many large clinical systems, including Planned Parenthood, have decided to stop using misoprostol vaginally, opting instead for use of this medication by mouth. "We will have to wait," she writes, "perhaps many months or years, but eventually we may see if this change in practice is accompanied by any measurable change in the rate of these tragic deaths."

Aldape and Winikoff agree that there are no clear measures yet identified to prevent this infection.  The infections are difficult to identify and, in the early stages, can mimic other, more common infections.  Both authors stress the need for further research to discover the factors that predispose to these infections so that preventive measures can be designed. 

Source: Infectious Diseases Society of America (IDSA)

 

 

Recent Videos
Jordan Bastian, MPH, CIC, at APIC25
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Related Content

CDC  (Adobe Stock, unknown)

CDC Urges Vigilance: New Recommendations for Monitoring and Testing H5N1 Exposures

Infection Control Today® Editorial Staff
July 11th 2025
Article

With avian influenza A(H5N1) infections surfacing in both animals and humans, the CDC has issued updated guidance calling for aggressive monitoring and targeted testing to contain the virus and protect public health.


IP LifeLine from Infection Control Today

IP LifeLine: Layoffs and the Evolving Job Market Landscape for Infection Preventionists

Brenna Doran, PhD, MA, ACC, CIC
July 11th 2025
Article

Infection preventionists, once hailed as indispensable during the pandemic, now face a sobering reality: budget pressures, hiring freezes, and layoffs are reshaping the field, leaving many IPs worried about their future and questioning their value within health care organizations.


Washing hands at a sink  (Adobe Stock 1298928756)

A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings

Kerri Simone, MPH, CIC;Alexander O’Flaherty Linehan ;Will Zacamy
July 9th 2025
Article

Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.


Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.

Related Content

CDC  (Adobe Stock, unknown)

CDC Urges Vigilance: New Recommendations for Monitoring and Testing H5N1 Exposures

Infection Control Today® Editorial Staff
July 11th 2025
Article

With avian influenza A(H5N1) infections surfacing in both animals and humans, the CDC has issued updated guidance calling for aggressive monitoring and targeted testing to contain the virus and protect public health.


IP LifeLine from Infection Control Today

IP LifeLine: Layoffs and the Evolving Job Market Landscape for Infection Preventionists

Brenna Doran, PhD, MA, ACC, CIC
July 11th 2025
Article

Infection preventionists, once hailed as indispensable during the pandemic, now face a sobering reality: budget pressures, hiring freezes, and layoffs are reshaping the field, leaving many IPs worried about their future and questioning their value within health care organizations.


Washing hands at a sink  (Adobe Stock 1298928756)

A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings

Kerri Simone, MPH, CIC;Alexander O’Flaherty Linehan ;Will Zacamy
July 9th 2025
Article

Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.


Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.

Advertise
About Us
Editorial Board
Contact Us
Job Board
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Commerce Drive
Cranbury, NJ 08512

609-716-7777

© 2025 MJH Life Sciences

All rights reserved.
Home
About Us
News