Researchers Find New Cultivation System to Battle Cryptosporidium

A research team at the University of Kent has established the first long-term cultivation system at a laboratory scale for the parasite Cryptosporidium, one of the world's worst and most common causes of diarrhea and death from diarrhea.

Cryptosporidium causes the diarrheal disease Cryptosporidiosis, which is usually spread by contaminated water supplies. The important role of Cryptosporidium as a cause of diarrhea has been established in recent years, and outbreaks feature regularly in news headlines. Cryptosporidium-caused diarrhea is the second major cause of death from childhood diarrhea. In addition, individuals with an impaired immune system are at great risk.

There are no treatments for Cryptosporidium and so far, research on it has been limited, because the parasite could not be cultivated at a laboratory scale. Research led by Dr. Anastasios Tsaousis and professor Martin Michaelis of the School of Biosciences has now established the first long-term cultivation system for Cryptosporidium parasites at a laboratory scale.

This new cultivation system will transform research on Cryptosporidium; it will enable large-scale screening for anti-Cryptosporidium drugs as well as enable many laboratories all over the world to investigate the parasite. It will also enable the studying of the parasite biology in unprecedented detail and will allow, for the first time, the long-term storage of the parasite. It will dramatically reduce the number of animals needed for the investigation and production of the parasite, and the team has already gained important new insights into the life cycle of the parasite.

In addition to Tsaousis and Michaelis and their laboratory members, other scientists from the University of Kent have contributed to this research including Dr Jane Povey, Ian Brown, and Dr Wei-Feng Xue from the School of Biosciences and Dr Mark Price from the School of Physical Sciences.

The results are now published in the International Journal of Parasitology.

Source: University of Kent