SAN DIEGO -- Researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have identified the bacteria Sphingomonas as containing a glycolipid which naturally triggers an immune response from the body's natural killer (NK) T cells. The finding sheds some light on the powerful, but little understood, workings of the NK T cells and will help scientists explore their possible use in fighting tumors and dangerous disease-causing bacteria.
In the paper, "Recognition of bacterial glycosphingolipids by natural killer T cells," to be published March 24, 2005 in the scientific journal Nature, Mitchell Kronenberg, PhD, and an international team of scientists working at the Scripps Research Institute, the Rockefeller University, New York University, and Kanto Gakuin University in Japan found that NK T cells, a type of white blood cell, exposed to the Sphingomonas bacteria's glycolipid quickly launched an immune assault to rid the body of the substance and bacteria carrying it.
Most white blood cells respond to foreign proteins to protect the body, but NKT cells are unique in that they respond to glycolipids, which are natural biochemicals made of linked fat and sugar. Previously, only one compound, developed by a pharmaceutical company in the 1990s, was known to activate the NK T cells. In a surprising twist, that compound was initially discovered in marine sponges. The compound was found to have anti-tumor activity and is currently in clinical trials for several tumor types. Because the NK T cells are known to be responsible for the tumor fighting mechanism induced by the marine sponge compound, and because their mechanism of action has been so mysterious, the NK T cells have generated increased research interest over the last several years.
Kronenberg and his lab have concentrated their studies on NK T cells since the cells were first discovered about 10 years ago. "They've been the subject of significant scientific interest because they initiate such a fast and vigorous immune response, which makes them very useful for anti-tumor responses and protection from infections," he said.
In particular, scientists wanted to know what substance would naturally activate the NK T cells. "Although the synthetic compound was useful for many studies, we wanted to know what substance would normally cause the NK T cells to produce an immune response, and it was not believable that marine sponges normally stimulate our immune system," said Kronenberg, who is also LIAI's president and scientific director. "We've found a bacteria in nature (Sphingomonas) that can activate these cells. We strongly suspect these cells may also have the capability of fighting other types of bacteria that can cause serious diseases. This is an exciting possibility that needs to be further explored." He added that the Sphingomonas bacteria are found throughout the environment but only rarely cause disease, perhaps because of the activity of NK T cells.
Kronenberg said the finding of a natural activator from bacteria will allow scientists to learn more about how NK T cells stimulate other cells of the immune system to fight infection and tumors.
Source: La Jolla Institute for Allergy and Immunology
A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings
July 9th 2025Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.
Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers
July 4th 2025Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.
How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels
July 3rd 2025Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.