News
ICViewExpert PerspectivesMedical World NewsPathogen PlaybookVideosWebinars
Conference CoverageConference ListingAPIC Chapters
Infection Control TodaySupplements And Featured Publications
CME/CEEditorial Advisory BoardJob BoardPartnersSponsoredWhitepapers
Subscribe
Educator of the Year Official Rules2024 Educator of the Year Winner2023 Educator of the Year WinnerEducator of the Year
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
Spotlight -
  • IC Trends
  • Bug of the Month
  • Featured Articles
  • Featured Columns
  • Pathogen Playbook
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
    • News
    • Subscribe
Advertisement

Tick-Related Disease Thrives on Cholesterol

July 5, 2007
Article

People who have high cholesterol levels may be much more susceptible to a particular disease transmitted by the bites of ticks, a new study in mice suggests.

Scientists infected mice with Anaplasma phagocytophilum, the bacterium that causes human granulocytic anaplasmosis (HGA), a disease with flu-like symptoms. Bacteria levels were 10 times greater in mice that were genetically predisposed to high cholesterol levels and that were also fed a high-cholesterol diet.

The results confirmed what the researchers had suspected that A. phagocytophilum depends on its hosts cholesterol stores for its survival.

The implication is that the higher a persons cholesterol levels, the more susceptible that person may be to developing a severe case of HGA, said Yasuko Rikihisa, the studys lead author and a professor of veterinary biosciences at OhioStateUniversity.

Yet HGA is difficult to accurately diagnose, as symptoms are similar to those of the flu and include high fever, muscle aches, chills and headaches. But in some cases misdiagnosis can be devastating.

Young, healthy people probably dont develop very severe symptoms, Rikihisa said. But left undetected, the infection could kill an older person or someone with a weakened immune system.

She added that immune function slowly declines and blood cholesterol levels typically increase as we age.

The researchers report their findings in a recent issue of the Journal of Infectious Diseases. Rikihisa conducted the study with Qingming Xiong and Xueqi Wang, both graduate students in Rikihisas laboratory.

Experts say that HGA is on the rise in the United States, where anywhere from 400 to more than 1,000 people contract the disease each year. It is transmitted by the bite of Ixodes scapularis, or deer tick. Deer ticks also spread Lyme disease, and are found primarily in the upper Midwest, New England, parts of the mid-Atlantic States and northern California.

The disease attacks immune cells called granulocytes, which the body normally uses to destroy infectious pathogens.

In the current study, Rikihisa and her colleagues studied two groups of mice. Animals in one group lacked a protein important for maintaining normal blood cholesterol levels, while mice in the other group had this protein, called apoliprotein E (apoE).

For about a month several mice from each group ate a diet high in cholesterol, while the rest of the animals ate a diet with normal cholesterol levels. At the end of the month, some of the mice from each feeding group were infected with A. phagocytophilum.

Ten days after infecting the mice, the researchers collected blood samples from each mouse and also harvested each animals spleen and liver. They determined the extent of the infection based on the amount of bacteria found in each tissue. Since the spleen and liver both filter blood, and the liver makes and stores cholesterol, the researchers thought that they may find higher concentrations of bacteria in these organs.

A. phagocytophilum levels were 10 times higher in mice predisposed to high blood cholesterol levels and that ate the high-cholesterol diet than in any other group of mice, including the animals that were predisposed and ate a normal-cholesterol diet.

 

Bacterium levels were highest in the blood and the spleen, and were quite low in the liver of any of the mice.

Cholesterol levels increased four times in the mice that ate the high-cholesterol diet and that were predisposed to high cholesterol. Yet cholesterol levels remained normal in the mice which had the cholesterol predisposition but consumed the normal-cholesterol diet.

Some people have mutations in the apoE gene, which controls apoE production. As a result, they cannot adequately maintain blood cholesterol. In humans, this mutation can cause blood cholesterol levels to significantly increase when they eat a diet high in cholesterol, Rikihisa said.

A high-cholesterol diet really boosted infection levels in the mice without apoE, Rikihisa said. The findings suggest that humans may be more susceptible to HGA if they eat a high-cholesterol diet and if they are otherwise prone to high blood cholesterol levels.

Studies by other researchers have found a link between older age and the level of A. phagocytophilum infection. In one study, infected patients averaged 51 years old, while 39 was the average age for a person infected with Lyme disease.

Our blood cholesterol levels generally rise as we age, Rikihisa said. Someone who suspects he was bitten by a tick needs to seek prompt antibiotic therapy. Additionally, lowering cholesterol levels through diet or with medication may help decrease the chance of developing HGA, or at least reduce the severity of its symptoms.

A grant from the National Institutes of Health supported this work.

Source: OhioStateUniversity    

 

 

 

 

 

Recent Videos
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Mark Wiencek, PhD
Rebecca Crapanzano-Sigafoos, DrPH, CIC, AL-CIP, FAPIC
The CDC’s updated hospital respiratory reporting requirement has added new layers of responsibility for infection preventionists. Karen Jones, MPH, RN, CIC, FAPIC, clinical program manager at Wolters Kluwer, breaks down what it means and how IPs can adapt.
Studying for the CIC using a digital tablet and computer (Adobe Stock 335828989 by NIKCOA)
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Infection Control Today's Conversations with the HSPA President, Arlene Bush, CRCST, CER, CIS, SME, DSMD, CRMST
Cheron Rojo, BS, FCS, CHL,  CER, CFER, CRCST
Matthias Tschoerner, Dr Sc
Standardizing Cleaning and Disinfection
Related Content

Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.


A Profession Without a Path, Part 2

Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers

Shahbaz Salehi, MD, MPH, MSHIA;Anna Arifin, MD, MBA, MT, CIC
July 4th 2025
Article

Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.


Stretcher and HAIs  (Image courtesy of author through AI)

How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels

Donald Sipp, MBA, RESE, CHESP, CHTI-2, CMIP, PMP
July 3rd 2025
Article

Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.


Hot Topics With Saskia v. Popescu, PhD, MPH, MA, CIC, FAPIC

Hot Topics for IPC on July 2, 2025

Saskia v. Popescu, PhD, MPH, MA, CIC, FAPIC
July 2nd 2025
Article

This Hot Topics for IPC covers the latest on ASPR, AMR, vaccines, and a study on AMR and livestock manure from Michigan State University.

Related Content

Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.


A Profession Without a Path, Part 2

Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers

Shahbaz Salehi, MD, MPH, MSHIA;Anna Arifin, MD, MBA, MT, CIC
July 4th 2025
Article

Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.


Stretcher and HAIs  (Image courtesy of author through AI)

How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels

Donald Sipp, MBA, RESE, CHESP, CHTI-2, CMIP, PMP
July 3rd 2025
Article

Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.


Hot Topics With Saskia v. Popescu, PhD, MPH, MA, CIC, FAPIC

Hot Topics for IPC on July 2, 2025

Saskia v. Popescu, PhD, MPH, MA, CIC, FAPIC
July 2nd 2025
Article

This Hot Topics for IPC covers the latest on ASPR, AMR, vaccines, and a study on AMR and livestock manure from Michigan State University.

Advertise
About Us
Editorial Board
Contact Us
Job Board
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Commerce Drive
Cranbury, NJ 08512

609-716-7777

© 2025 MJH Life Sciences

All rights reserved.
Home
About Us
News