Biofilm Formation on Catheters: Is a Resistance-Proof Solution Within Reach?
December 2nd 2010Patients fitted with long-term indwelling bladder catheters often face a serious complication: bacteria, most commonly Gram-negative Proteus mirabilis, can easily colonize and encrust the catheter. This eventually leads to the formation of a crystalline biofilm, consisting of mucopolysaccharide, that blocks the normal flow of urine from the bladder. Current methods for unblocking encrusted catheters by mechanical means, such as saline solution, replacing the catheter, or by using agents that try to dissolve the biofilm crystals, do not provide satisfactory results.