Invasive Fungal Infections Among Ventilated HSCT Patients in the ICU
Invasive fungal infection (IFI) is associated with high morbidity and high mortality in hematopoietic stem cell transplantation (HSCT) patients. Chen-Yiu Hung, of the Department of Thoracic Medicine at Chang Gung Memorial Hospital in Taipei, Taiwan, and colleagues, sought to assess the characteristics and outcomes of HSCT patients with IFIs who are undergoing mechanical ventilation (MV) at a single institution in Taiwan.
Â
The researchers performed an observational retrospective analysis of IFIs in HSCT patients undergoing MV in an intensive care unit (ICU) from 2000 to 2009. The characteristics of these HSCT patients and risk factors related to IFIs were evaluated. The status of discharge, length of ICU stay, date of death and cause of death were also recorded.
Â
There were 326 HSCT patients at the Linkou Chang-Gung Memorial Hospital (Taipei, Taiwan) during the study period. Sixty of these patients (18 percent) were transferred to the ICU and placed on mechanical ventilators. A total of 20 of these 60 patients (33 percent) had IFIs. Multivariate analysis indicated that independent risk factors for IFI were admission to an ICU more than 40 days after HSCT, graft versus host disease (GVHD), and high dose corticosteroid (p < 0.01 for all). The overall ICU mortality rate was 88 percent (53 of 60 patients), and was not significantly different for patients with IFIs (85 percent) and those without IFIs (90 percent, p = 0.676).
The researchers concluded that there was a high incidence of IFIs in HSCT patients requiring MV in the ICU in their study cohort. The independent risk factors for IFI are ICU admission more than 40 days after HSCT, GVHD, and use of high-dose corticosteroid. Their research was published in BMC Infectious Diseases.
Reference: Hung C-Y, et al. Invasive fungal infection among hematopoietic stem cell transplantation patients with mechanical ventilation in the intensive care unit. BMC Infectious Diseases 2012, 12:44 doi:10.1186/1471-2334-12-44
APIC Salutes 2025 Trailblazers in Infection Prevention and Control
June 18th 2025From a lifelong mentor to a rising star, the Association for Professionals in Infection Control and Epidemiology (APIC) honored leaders across the career spectrum at its 2025 Annual Conference in Phoenix, recognizing individuals who enhance patient safety through research, leadership, and daily practice.
Building Infection Prevention Capacity in the Middle East: A 7-Year Certification Success Story
June 17th 2025Despite rapid development, the Middle East faces a critical shortage of certified infection preventionists. A 7-year regional initiative has significantly boosted infection control capacity, increasing the number of certified professionals and elevating patient safety standards across health care settings.
Streamlined IFU Access Boosts Infection Control and Staff Efficiency
June 17th 2025A hospital-wide quality improvement project has transformed how staff access critical manufacturer instructions for use (IFUs), improving infection prevention compliance and saving time through a standardized, user-friendly digital system supported by unit-based training and interdepartmental collaboration.
Swift Isolation Protocol Shields Chicago Children’s Hospital During 2024 Measles Surge
June 17th 2025When Chicago logged its first measles cases linked to crowded migrant shelters last spring, one pediatric hospital moved in hours—not days—to prevent the virus from crossing its threshold. Their playbook offers a ready template for the next communicable-disease crisis.
