NIH Scientists Develop Way to Make Old Antibiotic Work Against TB

Article

Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed a method to synthesize modified forms of an established antibiotic called spectinomycin. The modified forms, unlike the original drug, can act against tuberculosis (TB) bacteria. The new compounds overcome a pump mechanism that TB bacteria ordinarily use to expel standard spectinomycin and were highly effective when tested in mice with either acute or chronic TB infection.

Richard Lee, PhD, of St. Jude Children's Research Hospital in Memphis, Tenn., and Anne Lenaertes, PhD, of Colorado State University in Fort Collins, Co. led the research. In test tube experiments, the new compounds, collectively termed spectinamides, were narrowly targeted to TB bacteria and closely related bacteria, showed activity against multidrug-resistant and extensively drug-resistant TB bacteria, and did not harm mammalian cells. These characteristics suggest that spectinamides may work well against TB bacteria while avoiding harm to normally occurring gut bacteria.

The research was published online this week and was supported by grant AI090810 and by NIAID contract HHSN272201000009I/01.

Reference: Lee RE, et al. Spectinamides: A new class of semisynthetic anti-tuberculosis agents that overcome native drug efflux. Nature Medicine DOI: 10.1038/NM.3458 (2014).

Source: NIH 

Related Videos
NFID Medical Director, Robert H. Hopkins, Jr., MD  (Photo courtesy by Evoke Kyne)
Shelley Summerlin-Long, MPH, MSW, BSN, RN, senior quality improvement leader, infection prevention, UNC Medical Center, Chapel Hill, North Carolina
Infection Control Today Infection Intel: Staying Ahead with Company updates and product Innovations.
An eye instrument holding an intraocular lens for cataract surgery. How to clean and sterilize it appropriately?   (Adobe Stock 417326809By Mohammed)
Christopher Reid, PhD  (Photo courtesy of Christopher Reid, PhD)
Paper with words antimicrobial resistance (AMR) and glasses.   (Adobe Stock 126570978 by Vitalii Vodolazskyi)
3D illustration: Candida auris   (Adobe Stock 635576411 By Niamh )
 MIS-C (Adobe Stock 350657530 by Bernard Chantal)
Set of white bottles with cleaning liquids on the white background. (Adobe Stock 6338071172112 by zolnierek)
Related Content