Respiratory and intestinal infections caused by RNA viruses stimulate infected cells to produce interferons, which can act alone or in combination to block virus replication. Important differences between the presence of IFN receptors on cells and new evidence that specific types of IFNs can control RNA virus infection are explored in a review article in Journal of Interferon & Cytokine Research (JICR), a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the JICR website.
In "Type-I and III Interferon Production in Response to RNA Viruses," Elizabeth Reid and Bryan Charleston, the Pirbright Institute (Surrey, UK), review the most recent studies looking at how RNA virus infections are able to induce multiple signaling pathways in host cells. As a result, different types of interferons are produced, each with distinct antiviral properties.
"The interferon system plays a critical role in maintaining an optimum equilibrium between virus replication and host survival," says co-editor-in-chief Ganes C. Sen, PhD, chairman of the Department of Molecular Genetics at Cleveland Clinic Foundation in Ohio. "This review describes how RNA viruses achieve this balance by regulating the synthesis of Type I and Type III interferons."
Source: Journal of Interferon & Cytokine Research (JICR)
Outbreak Detection, Patient Protection: The Legal Upside of Genomics in Infection Prevention
May 21st 2025A string of infections following routine knee surgeries in Tennessee has escalated into litigation, raising questions about how—and when—health care facilities should detect outbreaks. As genomic surveillance gains traction in infection prevention, some fear it could increase legal risk. In reality, it may offer hospitals their strongest legal defense.
Silent Saboteurs: Managing Endotoxins for Sepsis-Free Sterilization
Invisible yet deadly, endotoxins evade traditional sterilization methods, posing significant risks during routine surgeries. Understanding and addressing their threat is critical for patient safety.
Outbreak Detection, Patient Protection: The Legal Upside of Genomics in Infection Prevention
May 21st 2025A string of infections following routine knee surgeries in Tennessee has escalated into litigation, raising questions about how—and when—health care facilities should detect outbreaks. As genomic surveillance gains traction in infection prevention, some fear it could increase legal risk. In reality, it may offer hospitals their strongest legal defense.
Silent Saboteurs: Managing Endotoxins for Sepsis-Free Sterilization
Invisible yet deadly, endotoxins evade traditional sterilization methods, posing significant risks during routine surgeries. Understanding and addressing their threat is critical for patient safety.
2 Commerce Drive
Cranbury, NJ 08512