Combatting Latex Allergies

September 1, 2002

Combatting Latex Allergies

By Chuck Mills, CRNA

Allergies to natural rubber latex (NRL) affect between 8 percent and 25
percent of healthcare workers (HCWs), especially nurses, exposed to products
containing latex on a regular basis.

According to the American College of Allergy, Asthma and Immunology (ACAAI),
"Latex allergy, or hypersensitivity, occurs when the body's immune system
reacts to proteins found in NRL. The immune system launches a 'defense' that can
cause a host of unpleasant, and in some cases, life-threatening symptoms. It is
the same type of generalized allergic reaction seen when individuals, who are
allergic to bee venom, receive a bee sting."

Although examination gloves cause most latex allergies, all hospital products
and supplies containing NRL, such as catheters, blood pressure cuffs and
anesthesia equipment, can trigger reactions in sensitized individuals. For a
complete list of medical devices, products and equipment containing latex, visit
the American Association of Nurse Anesthetists (AANA) Web site at
and access the "AANA Latex Allergy Protocol."

The first reported case of a latex allergy reported in medical literature
occurred in 1979 to a British woman who developed a hypersensitivity to her
household rubber gloves. European medical journals record about 50 such cases
between 1979 and 1988. In 1991, the U.S. Food and Drug Administration (FDA)
received more than 1,000 reports of latex allergies.

The incidence of latex allergies among HCWs has increased dramatically during
the past 20 years for several reasons. The introduction of standard precautions
-- including the use of latex gloves by HCWs to prevent the spread of bloodborne
diseases, such as AIDS, HIV and hepatitis B -- primarily contributed to the rise
in allergies seen after 1979. Increased awareness and reporting of latex
allergies also revealed a higher prevalence of this hypersensitivity. In
addition, insufficient washing during NRL glove manufacturing may have
contributed to a rise in latex allergies. In 1991, the Food and Drug
Administration (FDA) outlined to manufacturers a two-step washing process, the
first to occur during leaching and the second after product completion, to
better remove allergenic proteins from latex.


Contact with mucous membranes, regular glove wearing and inhalation of
aerosolized proteins represent the most common ways to contract a latex allergy.
Ongoing exposure to products made from NRL or latex blends, especially skin
contact with gloves, cause most allergic reactions. Surgical procedures cause
some of the most severe reactions because latex comes into direct contact with
moist areas of the body and internal surfaces causing faster, easier absorption
of the allergen.

Airborne proteins, which enter the eyes or mucous membranes, also pose a
serious health threat. Latex proteins bind with the cornstarch powder lining
some types of gloves, then become released into the air when wearers snap-off
their gloves. B. Lauren Charous, MD, chair of the ACAAI's latex hypersensitivity
committee, calls powdered NRL gloves "the chief source of latex
aeroallergen in the medical setting."


The three recognized reactions to latex include non-allergic irritant contact
dermatitis, type IV cell-mediated allergies and type I IgE-mediated allergies.

Non-allergic irritant contact dermatitis, a skin rash, is the most common
reaction affecting regular wearers of powdered and non-powdered latex gloves.
Symptoms include dry, crusted patches in the glove area also caused by certain
types of cleaners, repeated hand washing and incomplete hand drying.

Type IV cell-mediated allergies, the most common immune system reaction to
latex, affect 82 percent of individuals allergic to rubber products. A delayed
hypersensitivity to one or more of the 300-plus chemicals used to manufacture
latex, type IV allergies produce allergic contact dermatitis within 48 to 96
hours of exposure. Continued exposure puts individuals with a type IV allergy at
risk of developing the antibodies that can trigger a type I latex allergy.

Type I IgE-mediated allergies represent an immediate hypersensitivity to
actual latex proteins and include two subgroups. The first causes hives, itchy
and watery eyes, runny nose, sneezing, wheezing, asthma, abdominal pain, nausea,
diarrhea and skin rashes. The second, and more serious, causes anaphylaxis, a
severe immune system reaction characterized by breathing difficulties and low
blood pressure that can cause shock or even death.


Though no cure exists, non-allergic skin rashes can be treated with
doctor-prescribed or over-the-counter ointments, creams or jellies. Patients
should not use petroleum jelly and wear gloves at the same time since petroleum
products destroy the barrier of protection provided by latex.

Patients with type IV allergies can use the aforementioned treatments to
relieve skin irritations and should avoid the latex gloves or rubber products
suspected of causing the dermatitis.

Type I allergic reactions can only be treated by avoiding latex exposure
altogether. This requires healthcare workers to wear vinyl or non-latex gloves
and work in areas that prohibit powdered glove use. The 1991 Bloodborne
Pathogens Standard issued by the Occupational Safety and Health Administration (OSHA),
states, "Glove liners, powderless gloves, or other alternatives must be
readily accessible to employees who are allergic to the gloves normally

However, the use of powder-free gloves does not guarantee a safe environment
for HCWs. Under current government standards, gloves labeled as powder-free can
contain up to 2 milligrams of powder per glove, enough to trigger allergic
reactions in sensitized individuals. The following outlines steps that HCWs can
take to minimize their exposure to latex:

  • Wear low-protein or powder-free gloves.
  • Reduce the amount of time gloves are worn.
  • Wash hands with a pH-balanced soap and dry thoroughly between glove use to
    remove latex proteins and prevent skin irritations.
  • Avoid oil-based hand creams and lotions, which deteriorate gloves and
    accelerate the release of latex allergens.
  • Remove gloves hourly to allow hands to air-dry.
  • Avoid snapping off gloves to prevent the release of airborne latex
  • Replace latex gloves with appropriate substitutes such as vinyl gloves.
  • Wear glove liners made of cotton or polymers, like hydrogel and silicone,
    under latex gloves.
  • Double or triple glove to reduce latex protein exposure to co-workers and
  • Remove latex-containing dust from the workplace.


HCWs need advance notice of a patient's latex sensitivity to provide
effective treatment and prevent medical complications. Patients should wear a
Medic-Alert bracelet and charts should be clearly flagged. A crash cart stocked
with latex-free gloves and equipment, and drugs for treating anaphylaxis, should
be on hand.

If a patient experiences a severe latex reaction, HCWs should notify
supervisors and physicians, complete an incident report and document nursing
interventions taken. Healthcare workers should retain the product suspected of
causing the reaction and follow hospital procedures to comply with the Safe
Medical Devices Act.

The AANA's aforementioned latex allergy protocol contains avoidance
precautions, patient care recommendations and emergency response and management
information. The protocol lists secondary pharmacological treatments,
non-pharmacological considerations, pre-medication agents, and common medical
devices, products and anesthesia equipment containing latex. It also provides
suggested reading materials and the Web sites of manufacturers who offer
latex-free healthcare products.


Skin prick, skin patch and radioallergosorbent (RAST) tests screen for latex
allergies. To perform the skin prick test, an allergist-immunologist injects the
latex proteins suspected of causing allergic reactions under the skin or to a
scratch or puncture wound on the patient's arm or back. These proteins produce a
small, raised, red area within 15 minutes of injection among allergic patients.
Skin prick tests, which can induce anaphylactic shock, should be performed only
under the supervision of an allergy specialist and with appropriate emergency
back-up equipment on hand.

Skin patch tests use the patient's glove or latex product to screen for an
immediate or delayed hypersensitivity and to evaluate the cause of the skin
irritation. Use of the latex product in question helps to ensure an accurate
diagnosis since no standardized patch test exists.

The RAST test identifies specific IgE antibodies to latex in the blood and
supports a NRL allergy diagnosis. The diagnostic success of this test approaches
100 percent.

The current unavailability of a standard by which to benchmark the skin
prick, skin patch and RAST tests can produce inconclusive results, such as false
positives and negatives. These inconsistencies may require further testing or a
diagnosis to be based on a patient's medical history. The FDA is expected to
approve a serum for standardized skin prick testing soon.


Safeguarding the welfare of patients and healthcare workers may require the
combined efforts of industry, medical specialists, patient groups and government
agencies according to the ACAAI which endorses content labeling for medical
devices containing NRL and elimination of the word "hypoallergenic"
from latex and non-latex glove descriptions.

Replacing latex examination gloves with non-latex substitutes represents a
proactive step toward creating a safe environment for patients and providers.
Although FDA figures indicate that synthetic rubber gloves exceed by more than
105 percent the price of their NRL counterparts, many institutions saved money
by converting to a latex-free environment.

In 1998, the University of Maryland Medical Center (UMMC) in Baltimore,
adopted a mandatory latex allergy screening policy for new employees and those
transferring to patient care services. Part of a five-year NRL glove conversion
plan, screening costs the institution $60,000 each year, but saves it more than
$1 million in projected annual worker's compensation claims. Ordering one type
of latex-free gloves also proved more cost-efficient than ordering several
different types of powdered and non-powdered latex gloves.

"An essential component of any institutional intervention program for
NRL allergy is early detection. While the medical center is converting to a
non-latex environment, we thought it was crucial to screen employees at risk so
that a safe work environment could be provided for them," explained Mary
Beth Bollinger, MD, UMMC's director of pediatrics.

Chuck Mills is a certified registered nurse anesthetist (CRNA) and a
member of the Occupational Safety and Hazard Committee for the American
Association of Nurse Anesthetists in Park Ridge, Ill.